Dukkhasutta
Sāvatthinidānaṁ. Atha kho aññataro bhikkhu …pe… ekamantaṁ nisinno kho so bhikkhu bhagavantaṁ etadavoca: “sādhu me, bhante, bhagavā saṅkhittena dhammaṁ desetu …pe… ātāpī pahitatto vihareyyan”ti. “Yaṁ kho, bhikkhu, dukkhaṁ; tatra te chando pahātabbo”ti. “Aññātaṁ, bhagavā, aññātaṁ, sugatā”ti.
Suffering
At Sāvatthī. Then a mendicant went up to the Buddha … and asked him, “Sir, may the Buddha please teach me Dhamma in brief. When I’ve heard it, I’ll live alone, withdrawn, diligent, keen, and resolute.” “Mendicant, give up desire for whatever’s suffering.” “Understood, Blessed One! Understood, Holy One!”